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There are many different recipes for meatloaf, but they all have one common factor – cooking time. Cooking meatloaf at 350 degrees for the perfect amount of time can be a little tricky. You want it to be cooked all the way through, but you don’t want to overcook it and make it dry. So, how long to cook meatloaf at 350 degrees? I will help you figure out the perfect cooking time for your meatloaf.
What Temperature Should Meatloaf Be Cooked To?
The ideal temperature for cooked meatloaf is 160 degrees Fahrenheit. This ensures that the meat is cooked all the way through and is juicy and moist.
To check the temperature of your meatloaf, insert a meat thermometer into the center of the loaf. If it reads 160 degrees, it is done. If it reads less than that, put it back in the oven and check it again in a few minutes.
How Do You Tell If A Meatloaf Is Fully Cooked?
There are a few ways to tell if your meatloaf is fully cooked. One way is to use a meat thermometer, as mentioned above. Another way is to cut into the center of the loaf and check to see if the juices run clear.
If the juices are still red or pink, that means the meatloaf needs to cook longer. If the juices are clear, that means the meatloaf is cooked through.
Is It Better To Cook Meatloaf Covered Or Uncovered?
There are two schools of thought when it comes to cooking meatloaf – covered or uncovered. Some people believe that cooking meatloaf covered will help it retain moisture and prevent it from drying out. Others believe that cooking meatloaf uncovered allows the fat to drip off, making for a leaner and healthier loaf.
If you are worried about your meatloaf drying out, you can cook it covered for part of the time and uncovered for the last few minutes. This will allow the fat to drip off while still keeping the meat moist.
How Long To Cook Meatloaf At 350?
Assuming your meatloaf is about four inches wide and eight inches long, you will need to cook it at 350 degrees for about 45 minutes to an hour.
If your meatloaf is smaller or larger, you will need to adjust the cooking time accordingly.
A good rule of thumb is to cook the meatloaf for about 15 minutes per inch of thickness.
So, if your meatloaf is six inches wide and eight inches long, you would need to cook it for about two hours.
Meatloaf Ingredients
Meatloaf:
- Ground beef (90% lean): 2 lbs
- White onion (diced): 1 large
- Eggs: 2
- Garlic cloves (minced): 2 tbsp
- Ketchup: 4 tbsp
- Worcestershire sauce: 1 tbsp
- Fresh parsley (finely chopped): 4 tbsp
- Panko breadcrumbs: 3/4 cup
- Milk: 1/2 cup
- Italian seasoning: 2 tsp
- Smoked paprika: 1/2 tsp
- Salt: 2 tsp
- Black pepper: 1/2 tsp
Meatloaf Sauce:
- Ketchup: 1 cup
- White vinegar: 2 tsp
- Brown sugar: 2 tbsp
- Garlic powder: 2 tsp
- Onion powder: 1 1/2 tsp
- Salt (to taste): 1/2 tsp
- Pepper (to taste):1/2 tsp
How To Cook Meatloaf At 350?
A delicious meatloaf is the perfect comfort food for a cold winter night. And this easy recipe will ensure that your meatloaf turns out juicy and flavorful every time.
1. To start, preheat your oven to 350 degrees Fahrenheit. Then, in a large bowl, mix together all of the meatloaf ingredients until well combined.
2. Once the mixture is uniform, shape it into a loaf and place it on a baking sheet lined with foil or parchment paper.
3. Bake the meatloaf for 45 minutes to an hour, or until it is cooked through.
4. While the meatloaf is baking, prepare the sauce by mixing together all of the sauce ingredients in a small bowl.
5. After the allotted baking time has passed, spread the sauce over the meatloaf and bake for an additional 5-10 minutes.
6. Finally, let the meatloaf rest for 10 minutes before slicing and serving. Enjoy!

Best Classic Meatloaf Recipe
Expert Tips And Tricks
– For a leaner meatloaf, substitute ground turkey or chicken for the ground beef.
– If you don’t have panko breadcrumbs, you can use regular breadcrumbs or even crushed up cereal flakes.
– To make sure your meatloaf is cooked through, insert a meat thermometer into the center of the loaf. If it reads 160 degrees, it is done.
– To prevent your meatloaf from drying out, you can cook it covered for part of the time and uncovered for the last few minutes. This will allow the fat to drip off while still keeping the meat moist.
– For a more flavorful meatloaf, add in some shredded cheese, diced peppers, or sautéed mushrooms.
– leftovers can be stored in the fridge for up to three days or in the freezer for up to two months.
– Reheating meatloaf is best done in a 350 degree oven until heated through. You can also reheat it in the microwave, but be careful not to overcook it or it will dry out.
– If you want to make mini meatloaves, simply shape the mixture into small loaves and cook for a shorter amount of time. You can also use a muffin tin to make individual meatloaves.
– For a fun twist, try shaping the meatloaf into a loaf and then top with mashed potatoes. Spread the potatoes over the top of the meatloaf and bake as directed. You can also add shredded cheese to the potatoes for an extra cheesy treat!
Why Do You Put Milk In Meatloaf?
The milk helps to keep the meatloaf moist and also adds a bit of richness. You can also use buttermilk, sour cream, or yogurt in place of the milk.
What Is The Best Filler For Meatloaf?
The best filler for meatloaf is breadcrumbs. You can use regular breadcrumbs, panko breadcrumbs, or even crushed up cereal flakes.
Should You Cook Onions Before Putting In Meatloaf?
No, you don’t need to cook the onions before putting them in the meatloaf. They will cook while the meatloaf is baking.
How Do You Keep Meatloaf Moist?
There are a few things you can do to keep meatloaf moist. One is to add some milk or other dairy product to the mixture. Another is to cook it covered for part of the time and uncovered for the last few minutes. This will allow the fat to drip off while still keeping the meat moist. You can also add some shredded cheese, diced peppers, or sautéed mushrooms to the mixture for extra flavor and moisture.
How Can I Make My Meatloaf Better?
There are a few things you can do to make your meatloaf better. One is to add some shredded cheese, diced peppers, or sautéed mushrooms to the mixture for extra flavor. Another is to cook it covered for part of the time and uncovered for the last few minutes. This will allow the fat to drip off while still keeping the meat moist. You can also try adding some barbecue sauce or ketchup to the top of the meatloaf for a fun twist.
How Long To Cook Meatloaf?
Cooking time for meatloaf will vary depending on the size and shape of your loaf. A general rule of thumb is to cook the meatloaf for 35-45 minutes. If you are using a mini muffin tin, the cooking time will be shorter. You can also insert a meat thermometer into the center of the loaf. If it reads 160 degrees, it is done.
How Long To Cook A 1 Lb Meatloaf?
A 1 lb meatloaf will take about 35-45 minutes to cook. You can also insert a meat thermometer into the center of the loaf.
How Long To Cook A 2 Lb Meatloaf?
A 2 lb meatloaf will take about an hour to an hour and a half to cook. You can also insert a meat thermometer into the center of the loaf. If it reads 160 degrees, it is done.
How Long To Cook A 3 Lb Meatloaf?
A 3 lb meatloaf will take about an hour and a half to two hours to cook. You can also insert a meat thermometer into the center of the loaf.
How Long To Cook Meatloaf At 375°F?
If you are cooking your meatloaf at 375°F, it will take about 25-30 minutes to an hour to cook.
How Long To Cook Meatloaf At 350°F?
If you are cooking your meatloaf at 350°F, it will take about 35-45 minutes to cook.
How Long Does It Take To Grill Meatloaf At 350?
A small 1 lb meatloaf will cook through in just 35 to 45 minutes at 350°F, while a larger 2 lb meatloaf will take closer to 1 hour and 20 minutes. And for a truly gargantuan 3 lb meatloaf, you’re looking at 1 hour and a half to 2 hours of cooking time. So next time you’re planning on making a meatloaf for dinner, be sure to factor in its size when deciding when to start cooking. Otherwise, you may end up with an overcooked (or undercooked) loaf of meat.
How Long Do You Cook Meatloaf At 350 In Air Fryer?
Traditionally, meatloaf is made by combining ground beef, bread crumbs, onion, and other seasonings, and then baking it in the oven. However, air frying meatloaf is a quick and easy way to achieve delicious results. Simply combine all of the ingredients, shape into a loaf, and air fry for 25 minutes. The result is a juicy and flavorful meatloaf that will be sure to please everyone at the table. So next time you’re in the mood for meatloaf, give air frying a try!

Bake Meatloaf At 350 In Oven
How Long Does It Take To Cook Frozen Meatloaf At 350?
If you’re cooking your meatloaf from frozen, it will take about 50% longer to cook. So a 1 lb meatloaf would take about 52-70 minutes to cook, while a 2 lb meatloaf would take about 1 hour and 40 minutes to 2 hours to cook. And for a 3 lb meatloaf, you’re looking at 2 hours and 30 minutes to 3 hours of cook time. So be sure to factor in the extra time when deciding when to start cooking your frozen meatloaf. Otherwise, you may end up with an overcooked (or undercooked) loaf of meat.
How Long Does It Take To Defrost Meatloaf Before Baking?
If you’re defrosting your meatloaf before baking, it will take about 24 hours for a 1 lb loaf, 48 hours for a 2 lb loaf, and 72 hours for a 3 lb loaf. So be sure to plan ahead and allow enough time for the meatloaf to defrost completely before cooking.
What Is Meatloaf Sauce Made Of?
There are many different recipes for meatloaf sauce, but they typically include ketchup, brown sugar, vinegar, and mustard. Some recipes also call for Worcestershire sauce, tomato paste, or BBQ sauce. Feel free to experiment and find a sauce that you like!
What To Serve With Meatloaf?
There are many different sides that go well with meatloaf. Some of our favorites include mashed potatoes, green beans, corn, and carrots. But really, the possibilities are endless! So get creative and find a side that you think will complement your meatloaf perfectly.
Why Does My Meatloaf Fall Apart?
There are a few reasons why meatloaf might fall apart. One possibility is that the ground beef was not properly mixed with the other ingredients. Another possibility is that the meatloaf was overcooked, which can cause it to be dry and crumbly. Finally, if the meatloaf was not allowed to rest for at least 10 minutes before slicing, it is more likely to fall apart. So be sure to keep these things in mind when making your meatloaf to help ensure that it turns out perfect every time!
How Do You Keep Meatloaf From Falling Apart?
There are a few things you can do to help keep your meatloaf from falling apart. First, be sure to mix the ground beef with the other ingredients until everything is evenly combined. Second, cook the meatloaf until it is just barely cooked through (about 160°F on a meat thermometer). And finally, allow the meatloaf to rest for at least 10 minutes before slicing. By following these tips, you should be able to keep your meatloaf from falling apart.
How To Make Meatloaf In Skillet?
If you don’t have an oven, or if you’re just looking for a quick and easy way to make meatloaf, try cooking it in a skillet on the stovetop. Simply combine all of the ingredients, shape into a loaf, and place in a large skillet over medium heat. Cook for about 25 minutes, or until the meatloaf is cooked through. Then, slice and serve as desired. So next time you’re in the mood for meatloaf, give this method a try!
How Do You Store Leftover Meatloaf At 350 In The Fridge?
Leftover meatloaf can be stored in the fridge for up to 3 days. To store, simply place the meatloaf in an airtight container and store in the fridge. When you’re ready to eat, simply reheat in the oven or microwave until heated through.
How To Freeze Cooked Meatloaf At 350?
Cooked meatloaf can be frozen for up to 3 months. To freeze, wrap the meatloaf tightly in foil or plastic wrap and place in a freezer-safe bag. Then, label and date the bag before placing in the freezer. When you’re ready to eat, thaw in the fridge overnight and reheat in the oven or microwave.
How To Reheat Cooked Meatloaf At 350?
Cooked meatloaf can be reheated in the oven or microwave. To reheat in the oven, preheat to 350°F and place the meatloaf on a baking sheet. Bake for about 10-15 minutes, or until heated through. To reheat in the microwave, place the meatloaf on a plate and heat for about 1-2 minutes, or until heated through.
Check Out Similar Recipe
FAQs About How Long To Cook Meatloaf At 350?
Is It Better To Cook Meatloaf At 350 Or 375?
There is no right or wrong answer to this question. It really depends on your personal preference. Some people prefer to cook meatloaf at a lower temperature, like 350°F, while others prefer to cook it at a higher temperature, like 375°F. Ultimately, it’s up to you to decide what temperature you want to cook your meatloaf at.
How Long Does It Take To Cook A 4 Lb Meatloaf At 350 Degrees?
It should take about 1 hour and 20 minutes to cook a 4 lb meatloaf at 350°F. However, cooking times may vary slightly depending on the size and shape of your meatloaf.
Is It Ok If My Meatloaf Is A Little Pink?
It is perfectly fine if your meatloaf is a little pink in the center. This simply means that it is not overcooked. However, if you are concerned about food safety, you can always cook the meatloaf for a few minutes longer until it is no longer pink in the center.
My Meatloaf Is Crumbling, What Can I Do To Fix It?
There are a few things you can do to help prevent your meatloaf from crumbling. First, be sure to mix the ground beef with the other ingredients until everything is evenly combined. Second, cook the meatloaf until it is just barely cooked through (about 160°F on a meat thermometer). And finally, allow the meatloaf to rest for at least 10 minutes before slicing. By following these tips, you should be able to keep your meatloaf from crumbling.
How Do I Know When My Meatloaf Is Done?
The best way to know if your meatloaf is done is to use a meat thermometer. The meatloaf is done when it reaches an internal temperature of 160°F.
What Can I Do With Leftover Meatloaf?
There are many things you can do with leftover meatloaf. You can eat it as-is, make meatloaf sandwiches, or even use it to make a meatloaf-based soup or stew. So if you have some leftover meatloaf, get creative and see what you can come up with!’
Summary
How long to cook meatloaf at 350? That all depends on the size of your meatloaf. A good rule of thumb is to cook it for 20-25 minutes per pound. So, if you have a three-pound meatloaf, you’ll want to cook it for about an hour and fifteen minutes. Keep in mind that cooking times may vary depending on your oven and the type of meat you’re using, so it’s always best to check doneness with a thermometer inserted into the center of the loaf. Once your meatloaf reaches an internal temperature of 160 degrees Fahrenheit, it’s ready to come out of the oven!
If you have any additional questions or tips, feel free to leave a comment below. And be sure to check out Liliana Kitchen other cooking related posts for more helpful information!

Ingredients
- 1. Meatloaf:
- - Ground beef (90% lean): 2 lbs
- - White onion (diced): 1 large
- - Eggs: 2
- - Garlic cloves (minced): 2 tbsp
- - Ketchup: 4 tbsp
- - Worcestershire sauce: 1 tbsp
- - Fresh parsley (finely chopped): 4 tbsp
- - Panko breadcrumbs: 3/4 cup
- - Milk: 1/2 cup
- - Italian seasoning: 2 tsp
- - Smoked paprika: 1/2 tsp
- - Salt: 2 tsp
- - Black pepper: 1/2 tsp
- 2. Meatloaf Sauce:
- - Ketchup: 1 cup
- - White vinegar: 2 tsp
- - Brown sugar: 2 tbsp
- - Garlic powder: 2 tsp
- - Onion powder: 1 1/2 tsp
- - Salt (to taste): 1/2 tsp
- - Pepper (to taste):1/2 tsp
Instructions
1. Preheat oven to 350 degrees Fahrenheit.
2. In a large bowl, mix together all of the meatloaf ingredients until well combined.
3. Shape the mixture into a loaf and place on a baking sheet lined with foil or parchment paper.
4. Bake for 45 minutes to an hour, or until the meatloaf is cooked through.
5. In a small bowl, mix together all of the sauce ingredients.
6. Spread the sauce over the meatloaf and bake for an additional 5-10 minutes.
7. Let the meatloaf rest for 10 minutes before slicing and serving. Enjoy!
Notes
- To make a leaner meatloaf, substitute ground turkey or chicken for the ground beef.
- If you don't have panko breadcrumbs, you can use regular breadcrumbs or even crushed up cereal flakes.
- To make sure your meatloaf is cooked through, insert a meat thermometer into the center of the loaf. If it reads 160 degrees, it is done.
- To prevent your meatloaf from drying out, you can cook it covered for part of the time and uncovered for the last few minutes to allow fat to drip off while still keepingmeat moist.
- For more flavorful meatloaf add in shredded cheese diced peppers or sautéed mushrooms
- Leftovers can be stored in fridge up to three days or freezer up to two months